Founded to end the donor shortage and the era of symptom-only care — building first-in-class therapies that repair, regenerate, and ultimately replace the failing heart.
Heart disease is the world's leading cause of death, yet most of medicine still only manages its symptoms. We exist to change that.
Advance a sequential pipeline of first-in-class bioengineered therapies — led by Lami-Pro™ for heart failure with preserved ejection fraction (HFpEF) — that reaches patients quickly while building toward a fully bioengineered, personalized human heart.
Launch products sequentially to generate early revenue and platform validation, fund the next breakthrough, and build a defensible IP estate spanning products, manufacturing, and delivery.

A pioneer of regenerative medicine with 30+ years in the field. Credited with the first functional cardiac repair with stem cells (1998) and perfusion decellularization (2008, Nature Medicine) — named a "Top 10 Research Advance" by the American Heart Association. Nominated to TIME's 100 Most Influential People (2009). Co-founder of Miromatrix Medical and Organamet Bio, and a longtime leader of regenerative-medicine research programs.

Cardiothoracic surgeon with 20+ years in cardiovascular research. Former Chief Medical Officer at an LVAD startup, leading clinical translation and regulatory strategy across cardiovascular device and biologic programs.

Commercial strategist driving investor relations, market access, and strategic partnership development — connecting the company's science to capital and commercialization partners.

Venture Partner and Managing Director of Manifest Capital Holdings LLC (MCH LLC), a St. Kitts and Nevis-based management consulting and investment advisory company.
Our board and advisory network spans clinical cardiology, regenerative science, advanced manufacturing, and finance.

CEO / President, Advanced Solutions Life Sciences.

Transplant Cardiologist, University of Florida. Former President, International Society of Heart and Lung Transplantation.

HLHS Parent & Advocate. Founder of Building the Cure Foundation.
A DoW-funded consortium of 150+ organizations led by Dean Kamen, and Organamet's R&D and manufacturing home in Manchester, New Hampshire.
Creators of the BioAssemblyBot® robotics and physical-AI platform that powers automated, scalable heart fabrication.
Engineering and device-development collaboration within the Kamen-led innovation ecosystem.